Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™
Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™ is formulated with ubiquinol, a highly bioavailable form of coenzyme Q10 nutrient, and augmented with the adaptogen PrimaVie ® shilajit, clinically shown to further increase CoQ10 absorption, promote cardiovascular health, and help restore youthful cellular energy.
Benefits at a Glance
- Super Ubiquinol CoQ10 absorbs up to 8 times better than ubiquinone CoQ10
- Promotes cellular energy production in heart, brain and muscle tissue
- Provides superior cardiovascular and antioxidant support
- PrimaVie® shilajit enhances mitochondrial CoQ10 absorption
- CoQ10 for heart health and cellular energy
CoQ10 (or coenzyme Q10) is an essential nutrient your body requires for healthy mitochondrial function, a process that produces body energy at the cellular level. Because of this, it makes sense that CoQ10 is concentrated in high-energy organs such as your brain,2 liver, kidneys, and (most importantly) your heart.
CoQ10 also has powerful antioxidant properties, protecting important proteins5 and mitochondrial DNA6 from oxidative damage. Unfortunately, CoQ10 levels in your body deplete over time.
Natural and unnatural causes of CoQ10 depletion
As we age, CoQ10 levels in our body naturally decrease. What’s more, popular statin drugs which are used to lower cholesterol, can also deplete CoQ10 levels in the blood and potentially in tissue.
And while statins have been shown to reduce plasma CoQ10 by nearly 40%, the normal aging process may be even worse: reducing CoQ10 levels in the heart muscle wall by as much as 72%.
Improved bioavailability: ubiquinol and shilajit
The traditional form of CoQ10, ubiquinone, is difficult for the body to absorb. But another form, ubiquinol, has been shown to absorb up to 8 times greater than ubiquinone. That’s why Life Extension offers a highly bioavailable form of Super Ubiquinol CoQ10 in a patented delivery system with superior absorption levels.
Shilajit enhances CoQ10 effectiveness
PrimaVie ® shilajit is an adaptogen shown to promote mitochondrial metabolism, helping mitochondria convert fats and sugars into ATP — the main source of cellular energy. When combined with ubiquinol CoQ10, it has been clinically shown to double levels of CoQ10 in the mitochondria. Shilajit prolongs CoQ10’s efficacy at the cellular level by stabilizing it in its ubiquinol form and facilitates greater cellular energy output by improving delivery of CoQ10 into the mitochondria.
In middle-aged mice, ubiquinol was up to 40% more effective at slowing measurements of aging compared to ubiquinone. In another preliminary study in mice, the combination of CoQ10 and shilajit produced a 56% increase in cellular energy production in the brain — 40% better than CoQ10 alone. Muscle tissue saw a 144% increase, which was 27% better than with CoQ10 by itself.
Breakthrough longevity and cellular energy formula
Research supports the value of this unique combination of ubiquinol CoQ10 and shilajit. That’s why we’ve created Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support™ ,to create a powerful synergy that supports heart health and youthful cellular energy production better than CoQ10 alone.
- Mol Biotechnol. 2007 Sep;37(1):31-7.
- Neuropsychiatr Dis Treat. 2009;5:597-610
- J Pharm Bioallied Sci. 2011 Jul;3(3):466-7.
- Biofactors. 2003;18(1-4):91-100.
- Biofactors. 1999;9(2-4):337-43.
- Zhonghua Er Bi Yan Hou Ke Za Zhi. 2004 Dec;39(12):707-11.
- Mitochondrion. 2007 Jun;7 Suppl:S168-74.
- Cardiol Rev. 2005 Mar-Apr;13(2):76-9.
- J Clin Pharmacol. 1993 Mar;33(3):226-9.
- Biofactors. 1999;9(2-4):291-9.
- Int J Food Sci Nutr. 2006 Nov-Dec;57(7-8):546-55.
- Ghosal S. Shilajit in Perspective. Alpha Science International Limited; 2006.
- Kaneka Corp. Unpublished study. 2007.
- Sci Total Environ. 1987 Apr;62:347-54.
- Environ Sci Technol. 2002 Jul 15;36(14):3170-5.
- Environ Sci Technol. 2002 May 1;36(9):1939-46.
- Environ Sci Technol. 2009 Feb 1;43(3):878-83.
- Systemic CoQ level in animals: Part II. Unpublished study. Natreon, Inc.; 2007.
- Pharmacologyonline. 2009;2:690-8.
- Electronic Journal of Biotechnology. 2008 Jul 15;11(3).
- Exp Gerontol. 2006 Feb;41(2):130-40.
- Pharmacologyonline. 2009;1:817-25.
Life Extension Super Ubiquinol CoQ10 with Enhanced Mitochondrial Support 100 mg
Life Extension has consistently introduced more potent and better absorbed forms of coenzyme Q10 since the product first came on the market in the early 80s. The new Super Ubiquinol with Enhanced Mitochondrial Support contains an organic compound called Prima Vie™ shilajit that research has shown to double levels of CoQ10 in the mitochondria. Shilajit has been shown to help restore and sustain cellular energy. The latest studies reveal that when shilajit is combined with CoQ10, cellular energy gains substantially increase.
In a breakthrough preliminary study, the combination of CoQ10 and shilajit produced a 56% increase in cellular energy production in the brain—40% better than CoQ10 alone. In muscle there was a 144% increase, or 27% better than CoQ10 alone.
Researchers have found that shilajit works to boost CoQ10’s beneficial effects by:
Stabilizing CoQ10 in its superior ubiquinol form, thereby prolonging its action at the cellular level. Facilitating more efficient delivery of CoQ10 into the mitochondria, resulting in greater cellular energy output. Scientific analysis shows that shilajit itself is rich in essential compounds that promote mitochondrial metabolism. Part of shilajit’s beneficial effects derives from its ability to help the mitochondria convert fats and sugars into adenosine triphosphate, or ATP—the body’s main source of energy.
Combining ubiquinol CoQ10 with shilajit generates a powerful synergy that supports more youthful cellular energy production than CoQ10 alone. What’s more, Life Extension has added this novel ingredient to its CoQ10 formulations without increasing the price.
Life Extension Frequently Asked Questions
What are Life Extension’s quality control standards?
Life Extension uses only premium quality vitamins and other ingredients. Their dedication to excellence insists that their nutritional supplements meet the highest standards and criteria.
That is why Life Extension insists on purchasing only the highest quality raw materials from all over the world, primarily from leading US, Japanese and European sources. Life Extension goes one step further by using advanced analytical methods, such as high-performance liquid chromatography and gas chromatography/mass spectrometry, to ensure their products meet label claims for potency and purity. Life Extension tests its raw materials using US Pharmacopeia and other exacting pharmaceutical assay standards.
Why are Life Extension’s nutritional supplements more advanced than other dietary supplements?
The unique ingredients included in Life Extension’s products are often years ahead of the products sold by commercial vitamin companies. Life Extension scientists analyze thousands of scientific studies every week to make sure their health-promoting formulas include the most advanced life extending ingredients in the world. The Foundation interacts with the world’s foremost gerontology researchers in order to obtain inside information about antiaging breakthroughs before these findings are published. The Life Extension Foundation funds the most advanced anti-ischemia laboratory in the world, where antioxidant vitamins, hormones, and pharmaceutical agents are used to prevent free radical induced cellular damage.
Are Life Extension’s vitamins natural or synthetic?
Life Extension carries a combination of natural and synthetic vitamins and supplements. Some advertising statements would have them believe that “natural” is better, but natural supplements in some instances contain impurities such as pollen and naturally occurring hormones that can cause problems for some people. Synthetic nutrients are manufactured to be chemically identical (with the exception of vitamin E) to those extracted from natural sources, and are the most pure nutrient vitamins.
What does Life Extension do to ensure the quality of its products?
They focus on three specific areas.
- Raw Materials: Unlike other supplement companies, the natural ingredients that go into Life Extension’s supplements are not chosen based on cost. Instead they are chosen based on purity (to exclude contaminants such as microbes and heavy metals), potency, and usage in successful scientific research.
- Validation of the Efficacy of Ingredients by Scientific Research: Life Extension uses ingredients and dosages that accurately replicate the most successful results obtained in scientific studies for maximum efficacy.
- Manufacturing: Naturally, Life Extension is in strict compliance with current Good Manufacturing Practice (GMP) for manufacturing, packaging, and storage.
Does the label accurately list exactly what’s in the bottle?
Yes. All active ingredients from patented, scientifically validated raw materials as well as final, finished products are verified using advanced analytical methods such as HPLC (highperformance liquid chromatography), MS (mass spectrometry), etc., to ensure each and every product accurately meets label claims in strict compliance with their demanding product specifications.
When it comes to supplements, is cost an indicator of quality?
Where Life Extension is concerned, yes. Patented materials validated in scientific studies cost more — period. In contrast with many commercial brands focused on driving up margins by using the cheapest raw materials available, Life Extension collaborates with raw material suppliers who invest in scientific validation of their ingredients, which increases material costs. With Life Extension products, you get the quality you pay for.
What are the “Other Ingredients” on the label, and why are they important?
They are inactive ingredients (excipients) that play a number of critical, essential roles in the manufacturing process including:
- Achieving uniform density for accurate dosing
- Dispersing the active ingredients evenly throughout a solid tablet, capsule, and softgel
- Protecting active ingredients from rapid inactivation due to heat and moisture
- Promoting tablet disintegration, as well as capsule and softgel dissolution
- Sustaining the release of active ingredients into the body over time
Why do some companies refer to these excipients as a threat to your health?
Claiming any product is “pure and free of excipients” can be deceptive advertising, too frequently used to draw attention away from inferior active ingredients! The right inactive ingredients used in the right way do important things … like ensuring that a tablet disintegrates in your GI tract rather than just passing through your system without benefit, or keeping a product from breaking down and being susceptible to microbes. Take Life Extension blueberry extract, for example. It contains AuroraBlue wild-harvested, Alaskan blueberries. To retain their nutritional complexity, these berries are freeze-dried and carefully milled for capsule formulation. But being a whole fruit raw material, it tends to want to reconstitute itself with moisture, which would make it a breeding ground for bacteria. So Life Extension uses a drying excipient to keep the milled blueberry material dry, so it can safely deliver its superior nutritional value compared with other, less costly blueberry extracts in most commercial formulations.
All of the excipients Life Extension uses have earned GRAS (“Generally Regarded As Safe”) status. In many cases not using them compromises final product quality! Excipients are used in nutritional supplements to ensure uniform density of complex active materials, to achieve even dispersion of active ingredients, and to promote appropriate disintegration and/or dissolution of active ingredients inside your body.
Should I be concerned about the use of stearic acid?
Stearic acid functions as a flow agent in the manufacture of quality products, and stearic acid also occurs naturally in the foods you eat. For example, four ounces of dark chocolate contain 3,625 mg of stearic acid; a cup of kidney beans contains 1,655 mg of stearic acid; an ounce of raw ground beef (grass-fed) contains 2,063 mg of stearic acid; and a half pound of lean raw turkey contains 1,642 mg of stearic acid. Even a tablespoon of allspice contains 1,513 mg of stearic acid! Life Extension supplements, on the other hand, typically contain no more than 10 mg per capsule. They always use the lowest level of magnesium stearate possible.
Should I be concerned that products with soybean oil or lecithin are a source of phytoestrogens?
While it is true that soy isoflavones are phytoestrogens, the amount in soybean oil or lecithin is so minute, the USDA lists it in foods as having zero value for isoflavones. To give you a frame of reference, Life Extension’s Ultra Natural Prostate contains 4 mg of lecithin which supplies only about 0.006 mg of soy isoflavones!
Should I be concerned with the usage of genetically modified plants (GMOs)?
Soybeans are an example of a crop that has used extensive genetic engineering to increase crop yield. The reality is that soybean oil and soy lecithin are highly processed derivatives of soy, far removed from their soy origin. Genetic modification doesn’t alter the entire plant, only a specific gene. Thus, specific molecules like soy lecithin are the same whether they come from a GMO or non-GMO soy source. However, due to their sensitivity to customer concerns, products with corn and soy-based active ingredients are in process of having the labels updated to list when soy and corn-derived active ingredients have been certified to be from non-GM food crops.
Does the gelatin used in softgels and capsules contain MSG?
Gelatin does not contain MSG, but does contain about 0.05 grams of glutamic acid in one softgel. You ingest about 120 times more glutamic acid in a serving of asparagus, cabbage or tomatoes!
What’s the difference between tablets, capsules and softgels?
Sophisticated products require sophisticated delivery systems. The best companies choose the most effective finished form based on the characteristics of the raw materials, and the desired disintegration or dissolution characteristics of the finished product and the active ingredients.
Why aren’t Life Extension products organic?
The word “organic” conveys the perception of quality to consumers. But it actually relates to foods that are grown rather than products that are formulated. Many of their scientifically validated raw materials are not produced organically. Rather, their mandate includes rigorous testing and scrupulous processing. The objective is purity, both in terms of our raw materials and their finished products.